Genetics Research
rs8636
Population Frequencies12
African
T 0.20201C 0.79799TT 0.043688TC/CT 0.316645CC 0.639666pop=53,012
African American
T 0.20345C 0.79655TT 0.044282TC/CT 0.318338CC 0.63738pop=51,172
African Others
T 0.162C 0.838TT 0.027174TC/CT 0.269565CC 0.703261pop=1,840
Asian
T 0.26721C 0.73279TT 0.08197TC/CT 0.370484CC 0.547546pop=11,126
East Asian
T 0.2478C 0.7522TT 0.072214TC/CT 0.3512CC 0.576587pop=8,918
European
T 0.355196C 0.644804TT 0.126952TC/CT 0.456487CC 0.41656pop=491,050
Latin American 1
T 0.2946C 0.7054TT 0.086902TC/CT 0.415385CC 0.497713pop=9,620
Latin American 2
T 0.30078C 0.69922TT 0.089509TC/CT 0.422532CC 0.487959pop=19,350
Other
T 0.32507C 0.67493TT 0.112298TC/CT 0.425537CC 0.462166pop=17,418
Other Asian
T 0.3456C 0.6544TT 0.121377TC/CT 0.44837CC 0.430254pop=2,208
South Asian
T 0.2949C 0.7051TT 0.095917TC/CT 0.397926CC 0.506157pop=3,086
Studies39
Unread Studies39 ▼
1
SNAP-25, a synaptic vesicle docking protein, carries a polymorphism (rs3746544) in its 3′-UTR region that is associated with ADHD, yet its functional mechanism remains …
2
Antipsychotics (AP) as well as other psychotropic drugs have long been known to have the potential to cause prolongation of the QT interval [12, 36]. Schizophrenia patients have …
3
Attention deficit/hyperactivity disorder (ADHD) is a hereditary neurodevelopmental disorder characterized by working memory (WM) deficits. The MnlI variant (rs3746544) of …
4
Vesicle-mediated membrane traffic is the mechanism fundamental to many biological events, especially the release of neurotransmitters. The main proteins of the mechanism that …
5
… An additional SNP, rs8636, was nominally associated with autism under the recessive model (C > T, Z = 1.972, P = .0487). Haplotype-based association test revealed that haplotypes …
6
Attention-deficit/hyperactivity disorder (ADHD) is a frequent chronic neuropsychiatric disorder in which different factors including environmental, genetic, and epigenetic …
7
Los fármacos antipsicóticos son ampliamente utilizados para el tratamiento de diversas enfermedades psiquiátricas, entre ellas la esquizofrenia. Existe una gran variabilidad en la …
8
ALTERACIÓN DE LA CAPACIDAD SENSORIOMOTORA EN EL TRASTORNO POR DÉFICIT DE ATENCIÓN CON O SIN HIPERACTIVIDAD ASOCIADA Page 1 ALTERACIÓN DE LA …
9
… The differences of frequency distribution of all haplotypes consisting of rs3746544-rs8636 between the case group and the control group were not statistically significant (P> 0.05). …
10
… The differences of frequency distribution of all haplotypes consisting of rs3746544-rs8636 between the case group and the control group were not statistically significant (P>0.05). …
11
12
Os critérios diagnósticos para o transtorno do déficit de atenção/hiperatividade (TDAH) não foram testados em adultos nos ensaios de campo realizados para embasar sua formulação …
13
… 由rs3746544-rs8636组成的所有单倍型在病例组与对照组间的频率分布差异均未见统计学 意义(均P>0.05).结论·在中国汉族人群中,SNAP25可能是SZ的易感基因,rs362998位点可能与SZ发病…
14
Currently, antipsychotics are the only type of drugs for the treatment of schizophrenia. The efficacy of antipsychotics in the treatment of schizophrenia is unsatisfactory. Specifically, more …
15
… Additionally, 101 subjects were genotyped for the rs8636 and rs3746544 single nucleotide polymorphisms (SNPs) of SNAP25. The genotype frequencies of rs8636 SNP significantly …
16
… STX1A (rs2228607), SYT1 (rs1880867 and rs2251214), VAMP2 (26bp Ins/Del) and SNAP25 (rs6108461 and rs8636) on a sample comprised of 548 adults with ADHD and 644 non-…
17
… And, the meta-analysis data for rs8636, rs362549, and rs362998 are the first time to be reported; however, no positive association was detected. In conclusion, we report some evidence …
18
… Adult patients homozygous for the C allele at SNAP25 rs8636 showed significantly higher total SNAP-IV scores (F = 11.215; adjusted P-value = 0.004). Impulsivity SNAP-IV scores were …
19
The etiology of Alcohol Dependence is multifactorial, resulting from the interplay of environmental and genetic factors, including variants in neurotransmission related …
20
… Excepting rs3746544 and rs8636, all the tested sites showed very low linkage disequilibrium between them. Data obtained in this preliminary study indicates that rs3746544 'T' allele …
21
… entre os polimorfismos STX1A-rs2228607 e SNAP25-rs8636 (p = 0.018). Esse resultado foi … para efeito de interação entre rs2228706 e rs8636). Nossos resultados corroboram achados …
22
Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-…
23
… Um dos SNPs abordados nesse trabalho de mestrado foi o rs8636, localizado na região 3’UTR do gene, o qual está em desequilíbrio de ligação com o SNP mais estudado (rs3746544)…
24
Bei der Behandlung schizophrener Patienten ist eine durch Antipsychotika ausgelöste Gewichtszunahme eine häufige Nebenwirkung, die oft zu einer Noncompliance hinsichtlich der …
25
… O terceiro trabalho sugere que o SNP rs8636 do gene SNAP25 está associado aos escores de sintomas totais de TDAH (F = 11,22; p = 0,004), enquanto o polimorfismo rs478597 do …
26
Antipsychotic drug-induced weight gain is a common adverse effect of antipsychotic medication in patients with schizophrenia. Many factors including genetic and environmental factors …
27
Attention deficit hyperactivity disorder (ADHD) is one of the most highly heritable behavioral disorders in childhood, with heritability estimates between 60 and 90 %. Family, twin and …
28
… сообщили об ассоциации между rs3746544 и rs8636 с уровнем триглицеридов в сыворотке. Полиморфизм rs1051312 был связан с увеличением индекса массы тела после …
29
In this research, we conducted a study of genes connected with the neurodevelopmental hypothesis of anorexia nervosa, using classical statistical and data-mining methods to establish …
30
… reported an association between rs3746544 and rs8636 and serum triglyceride levels. The … exact role of rs3746544, rs8636 and rs1051312 markers in weight gain and dyslipidemia. …
31
Attention deficit/hyperactivity disorder (ADHD) in children is a neurobehavioral disorder characterized by inattention, hyperactivity, and/or impulsivity. The biochemical abnormalities and …
32
… Therefore, it is not surprising that the same SNPs studied in psychiatric disorders were also shown to associate with weight gain (rs1051312), and with serum triglyceride levels (rs8636 …
33
Weight gain is an important side effect of antipsychotic drugs. Since the high interindividual difference in weight gain suggests that genetic factors play a role in this weight gain, studies …
34
… Intermarker LD analysis revealed rs8636 and rs3746544 were strongly correlated (D' = 1, r2 =0.997). 31 additional tag SNPs were combined with the original six independent SNPs to …
35
Drug induced weight gain is a serious side effect of several atypical antipsychotics. As genetic factors play an important role in the homeostasis of hunger/satiety we tried to replicate a …
36
The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 …
37
… Block 10, which contains the SNPs rs3746544, rs1051312, and rs8636 showed a global P-value of 0.278 in the FBAT analysis, which was not significant. Similarly, no significant …
38
The purpose of this study was to determine whether the single nucleotide polymorphisms (SNPs) within candidate genes for attention deficit hyperactivity disorder (ADHD) are …
39
Cell therapy with adult stem cells, particularly mesenchymal stem cells (MSC), has been progressively consolidated as a promising therapeutic approach for morphological and …
Curated Studies0 ▼
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