Genetics Research
rs7809234
Population Frequencies9
African
A 0.9018T 0.0982AA 0.812522AT/TA 0.178481TT 0.008996pop=5,558
African American
A 0.9026T 0.0974AA 0.814206AT/TA 0.176822TT 0.008972pop=5,350
African Others
A 0.88T 0.12AA 0.769231AT/TA 0.221154TT 0.009615pop=208
European
A 0.88436T 0.11564AA 0.780881AT/TA 0.206965TT 0.012154pop=17,114
Latin American 1
A 0.886T 0.114AA 0.789474AT/TA 0.192982TT 0.017544pop=228
Latin American 2
A 0.933T 0.067AA 0.870324AT/TA 0.124688TT 0.004988pop=802
Other
A 0.902T 0.098AA 0.818182AT/TA 0.168514TT 0.013304pop=902
South Asian
A 0.843T 0.157AA 0.745098AT/TA 0.196078TT 0.058824pop=102
Studies2
Unread Studies2 ▼
1
With a world-wide point prevalence of nearly one in twenty and as a leading cause of disability, major depressive disorder (MDD) has a large impact on global suffering. Effective treatment is key, however the majority of patients treated with first-line anti-depressant pharmacotherapy fail to achieve remission while few respond optimally. This treatment effect heterogeneity confounds clinical decisions made by providers and their patients. Accurately predicting those individuals who will and those who will not respond optimally to antidepressants would improve outcomes and decrease time and energy spent on ineffective therapies. This thesis details a project which utilized demographic, clinical, genomic, and metabolomic data from the Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study on 184 patients. A random forest algorithm was able to identify complex patterns in this baseline data to classify patient’s remission status at 8 weeks with 66% accuracy compared to 57% accuracy with a null-information model. Careful application of predictive algorithms may lead to more effective treatment of MDD.
2
Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share many structural and functional analogies, while their product metabolisms also follow similar patterns that are confluent in some metabolic steps. They are involved in common physiological functions, such as neurotransmission, gastrointestinal track function, immunity, cell growth and cell differentiation. As a consequence, metabolic elements of both BA subfamilies are also coparticipants in a long list of human diseases. This review summarizes the analogies and differences in their origin (HDC and DDC) as well as their common pathophysiological scenarios. The major gaps of information are also underlined, as they delay the possibility of holistic approaches that would help personalized medicine and pharmacological iniciatives for prevalent and rare diseases.
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