Genetics Research
rs721048
Population Frequencies12
African
G 0.95916A 0.04084GG 0.919855GA/AG 0.078612AA 0.001532pop=50,908
African American
G 0.95792A 0.04208GG 0.917426GA/AG 0.080989AA 0.001586pop=49,192
African Others
G 0.9948A 0.0052GG 0.98951GA/AG 0.01049AA 0pop=1,716
Asian
G 0.9501A 0.0499GG 0.90308GA/AG 0.094094AA 0.002826pop=7,078
East Asian
G 0.9504A 0.0496GG 0.903204GA/AG 0.094385AA 0.002411pop=5,806
European
G 0.8183A 0.1817GG 0.669331GA/AG 0.297938AA 0.032731pop=338,272
Latin American 1
G 0.8451A 0.1549GG 0.713848GA/AG 0.262561AA 0.023591pop=6,528
Latin American 2
G 0.83503A 0.16497GG 0.695957GA/AG 0.278145AA 0.025899pop=15,136
Other
G 0.85195A 0.14805GG 0.73094GA/AG 0.242025AA 0.027035pop=13,982
Other Asian
G 0.9489A 0.0511GG 0.902516GA/AG 0.092767AA 0.004717pop=1,272
South Asian
G 0.896A 0.104GG 0.802048GA/AG 0.187713AA 0.010239pop=586
Studies7
Unread Studies7 ▼
1
Prostate cancer (PC) is one of the most common oncological diseases among men. Up to 20% of PC cases are associated with hereditary risks or syndromes. The impact of common variants, particularly EHBP1 c.1185+30064G>A rs721048, on developing PC and other malignancies remains unclear. There are also no data on the frequency of this variant in the Kazakh population or its association with PC, nor its potential connection with other malignancies, particularly colorectal cancer (CRC). We utilized…
2
Prostate cancer is one of the five common cancers and has the second incidence rate and the third mortality rate in Iranian population. The purpose of this study was to evaluate the association of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839 (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma through multi-stage approach to identify the polymorphisms associated with prostate cancer and use them as screening factors. Screening tests can identify people who may have…
3
Prostate cancer is the third-most common form of cancer in men in Romania. The Romanian unscreened population represents a good sample to study common genetic risk variants. However, a comprehensive analysis has not been conducted yet. Here, we report our replication efforts in a Romanian population of 979 cases and 1027 controls, for potential association of 34 literature-reported single nucleotide polymorphisms (SNPs) with prostate cancer. We also examined whether any SNP was differentially as…
4
EHBP1 rs721048(A) was first identified as a prostate cancer (PCa) risk in Caucasians by genome-wide association study, but subsequent replication studies involving Caucasian and other ethnicities did not produce consistent results. The aim of this study was to obtain a more definite association between rs721048(A) and PCa risk. We comprehensively searched several databases updated to September 2014, including PubMed, Web of Science, EBSCO, and Google Scholar. Two authors independently screened a…
5
Prostate cancer (PCa) has the highest incidence among male malignancies in Western industrialized countries and, as a most common malignant disease in urology, its incidence has been increasing in recent years in Chinese men. This study was to investigate the risk loci associated with PCa susceptibility in Han Chinese by analyzing single nucleotide polymorphisms (SNP). We collected peripheral blood samples from 1 667 PCa patients and 1 525 healthy men, and detected 40 loci associated with PCa su…
6
Genome-wide association studies have identified multiple common alleles associated with prostate cancer risk in populations of European ancestry. Testing these variants in other populations is needed to assess the generalizability of the associations and may guide fine-mapping efforts. We examined 13 of these risk variants in a multiethnic sample of 2,768 incident prostate cancer cases and 2,359 controls from the Multiethnic Cohort (African Americans, European Americans, Latinos, Japanese Americ…
7
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than le…
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.