Genetics Research
rs6869645
Population Frequencies12
African
C 0.85075T 0.14925CC 0.725928CT/TC 0.249641TT 0.024432pop=37,574
African American
C 0.85177T 0.14823CC 0.727472CT/TC 0.248601TT 0.023927pop=36,444
African Others
C 0.8177T 0.1823CC 0.676106CT/TC 0.283186TT 0.040708pop=1,130
Asian
C 0.98041T 0.01959CC 0.961219CT/TC 0.038385TT 0.000396pop=10,108
East Asian
C 0.9797T 0.0203CC 0.959863CT/TC 0.039648TT 0.000489pop=8,172
European
C 0.936052T 0.063948CC 0.876479CT/TC 0.119146TT 0.004375pop=441,156
Latin American 1
C 0.9248T 0.0752CC 0.856608CT/TC 0.136481TT 0.00691pop=6,946
Latin American 2
C 0.97154T 0.02846CC 0.943487CT/TC 0.056103TT 0.000411pop=14,616
Other
C 0.93436T 0.06564CC 0.874287CT/TC 0.120137TT 0.005576pop=15,782
Other Asian
C 0.9835T 0.0165CC 0.966942CT/TC 0.033058TT 0pop=1,936
South Asian
C 0.9385T 0.0615CC 0.882856CT/TC 0.111221TT 0.005923pop=6,078
Studies14
Unread Studies14 ▼
1
Tourette Syndrome is a heritable neuropsychiatric disorder characterized by motor and vocal tics. Decades of research also implicate environmental factors in the occurrence of tics; most notable are complications during and around pregnancy. In this thesis I aimed to further our understanding of the genetic and environmental causes of tics.
2
The dopamine transporter is coded by the SLC6A3 gene and plays an important role in regulation of the neurotransmitter dopamine. To detect the association between the SLC6A3 …
3
Candidate gene effects consistently fail to replicate. However, because it is now known that most genetic effects are incredibly minute, samples of the size typically employed in psychological research were undoubtedly too small to detect the effects of individual candidate genes. In addition, research showing strong genetic correlation among mental disorders suggests data on multiple disorders and their symptoms is the most appropriate for uncovering the etiology of mental illness. That is, single gene, single disorder studies are underpowered. We tested whether the combined effect of 121 candidate genes was sufficient to predict psychopathology in a sample of 343 adolescents. A genetic risk score was created with highly precise effect estimates from a genome-wide association study (GWAS) on 337,199 people. To maximize the strength of this score, we used transdiagnostic p-factor model scores as our measure of psychopathology. The genetic risk scores failed to predict in our sample and were dwarfed by age and gender effects, mirroring the genes’ weak and mostly non-significant results in the GWAS. Our results are most consistent with the view that the candidate gene approach is obsolete. However, modern molecular genetics studies like GWAS currently lack detailed, thorough phenotype measurement. Future work should focus on developing high quality, deeply phenotyped data currently lacking in large consortia efforts.
4
Multiple Sclerosis (MS) is an immune-mediated, neuroinflammatory and neurodegenerative disorder affecting the central nervous system (CNS), first identified by Jean-Martin Charcot …
5
Many candidate gene studies use ‘intermediate phenotypes’ instead of disease diagnoses. It has been proposed that intermediate phenotypes have simpler genetic architectures such …
6
The dopamine transporter gene (SLC6A3, DAT) has been implicated in the pathogenesis of numerous psychiatric and neurodevelopmental disorders, including schizophrenia (SZ). We …
7
Schizophrenia and suicidal behaviour are sever and complex mental disorders, largely determined by factors of inheritance. Both disorders present pathological changes in the …
8
… Using these criteria, sex was included in the analysis of rs6869645 and body mass index was included for … As a result gender was included as a covariate for all analyses of rs6869645. …
9
To perform a comprehensive evaluation of association of common genetic variants in candidate genes in the dopaminergic pathway with schizophrenia in a sample from Croatian population.
10
Haplotype‐tagging SNP analyses were conducted to identify molecular genetic substrates of quantitative phenotypes derived from performance on a Continuous Performance Task (…
11
Previous studies have found heterogeneous association between DAT1‐3′‐UTR‐VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD − CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD − CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple‐test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD − CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD. © 2007 Wiley‐Liss, Inc.
12
Multipl Skleroz (MS); merkezi sinir sistemini (MSS) etkileyen, immun-aracılı, nöroinflamatuvar, nörodejeneratif bir hastalıktır. MS, hem ak hem gri maddede demiyelinizasyon ile görülen …
13
Several studies have provided evidence for a biological basis for problem gambling (PG): first-degree relatives (FDR) of PG subjects present a higher than expected …
14
Parkinson’s Disease (PD) is one of the most common neurodegenerative disease. The disease is represented by four cardinal features – Tremor, Rigidity, Akinesia and Postural Instability, resulted from motor impairments. The cognitive impairments, like dementia and depression, are also common in PD...
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