Genetics Genetics Research
CHROMOSOME 8 LINC00824 8q24.21 GENE VIEW LINC00824 · 8q24.21 8q23 8q25 rs6651252 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs6651252 T / C · LINC00824 · 8q24.21 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ T 5′ 3′ T HETEROZYGOUS 5′ 3′ T 5′ 3′ C HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ C 5′ 3′ C T Thymine — reference allele C Cytosine — variant allele genetics.jdge.cc

rs6651252

Gene: LINC00824 — Long Independently Transcribed Non-Coding RNA 824 Chr 8:128554935 8q24.21 Intron Variant
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total T 0.853943C 0.146057TT 0.733338TC/CT 0.24121CC 0.025451pop=788,722 ↬
African T 0.6705C 0.3295TT 0.45156TC/CT 0.437883CC 0.110557pop=64,926
African American T 0.67186C 0.32814TT 0.453556TC/CT 0.436613CC 0.109831pop=62,678
African Others T 0.6326C 0.3674TT 0.395907TC/CT 0.47331CC 0.130783pop=2,248
Asian T 0.95982C 0.04018TT 0.92295TC/CT 0.073741CC 0.003309pop=16,924
East Asian T 0.96784C 0.03216TT 0.937716TC/CT 0.060245CC 0.00204pop=12,748
European T 0.867825C 0.132175TT 0.75363TC/CT 0.228391CC 0.017979pop=632,844
Latin American 1 T 0.79476C 0.20524TT 0.630301TC/CT 0.328924CC 0.040776pop=11,036
Latin American 2 T 0.90913C 0.09087TT 0.827681TC/CT 0.162903CC 0.009416pop=24,002
Other T 0.86467C 0.13533TT 0.751897TC/CT 0.225543CC 0.022561pop=30,318
Other Asian T 0.9353C 0.0647TT 0.877874TC/CT 0.114943CC 0.007184pop=4,176
South Asian T 0.8928C 0.1072TT 0.797279TC/CT 0.190959CC 0.011762pop=8,672

Studies2

Unread Studies2 ▼
1

Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population.

Study ↗ PDF ↗
PID
Inflammatory bowel diseases (IBD) are chronic gastrointestinal inflammatory conditions comprising two major subtypes: Crohn's disease (CD) and ulcerative colitis (UC). The incidence of IBD is increasing in Asian countries including Malaysia. The aim of this study was to determine whether 32 single nucleotide polymorphisms (SNPs) strongly associated with IBD from genome-wide association studies, performed mainly in Caucasian populations, are associated with IBD in a Malaysian population, correlat…

2022 · Luu LDW, Popple G, Tsang SPW et al.

2

The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells.

Study ↗ PDF ↗
PID
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that are associated with a predisposition for developing IBD. For the majority, the causal variant and target genes affected are unknown. Here, we investigated the CD-associated SNP rs6651252 that maps to a gene desert region on chromosome 8. We demonstrat…

2019 · Matthews SM, Eshelman MA, Berg AS et al.

Curated Studies0 ▼

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

No curated studies yet.

Unused Studies0 ▼

No unused studies.