Genetics Genetics Research
CHROMOSOME 11 INTERGENIC GENE VIEW INTERGENIC ?q23 ?q25 rs6421571 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs6421571 T / A · INTERGENIC HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ T 5′ 3′ T HETEROZYGOUS 5′ 3′ T 5′ 3′ A HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ A 5′ 3′ A T Thymine — reference allele A Adenine — variant allele genetics.jdge.cc

rs6421571

Gene: INTERGENIC — Intergenic / Genome-wide Chr 11:118873063
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total T 0.198582C 0.801418TT 0.040831TC/CT 0.315503CC 0.643666pop=527,445 ↬
African T 0.2588C 0.7412TT 0.068466TC/CT 0.380679CC 0.550855pop=43,497
African American T 0.25828C 0.74172TT 0.068106TC/CT 0.380361CC 0.551533pop=41,877
African Others T 0.2722C 0.7278TT 0.077778TC/CT 0.388889CC 0.533333pop=1,620
Asian T 0.12759C 0.87241TT 0.017115TC/CT 0.220943CC 0.761942pop=12,854
East Asian T 0.1211C 0.8789TT 0.017566TC/CT 0.207068CC 0.775367pop=9,678
European T 0.197337C 0.802663TT 0.039688TC/CT 0.315298CC 0.645014pop=428,040
Latin American 1 T 0.1928C 0.8072TT 0.037338TC/CT 0.310906CC 0.651756pop=5,410
Latin American 2 T 0.127C 0.873TT 0.015568TC/CT 0.222806CC 0.761626pop=9,892
Other T 0.19067C 0.80933TT 0.037274TC/CT 0.306785CC 0.655941pop=20,014
Other Asian T 0.1474C 0.8526TT 0.015743TC/CT 0.263224CC 0.721033pop=3,176
South Asian T 0.163C 0.837TT 0.03205TC/CT 0.261825CC 0.706126pop=7,738

Studies3

Unread Studies3 ▼
1

CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma

Study ↗ PDF ↗
PID
Background: The chemokine receptor CXCR5 is selectively expressed on B cells; it is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principle ligand is CXCL13 or B lymphocyte chemoattractant. Three polymorphisms in the CXCR5 gene, rs148351692 C/G, rs6421571 C/T, and rs78440425 G/A, have been identified. Objective: To assess the genetic polymorphisms of CXCR5 and evaluate their possible contribution to the susceptibility and response to therapy of diffuse large B-…

2020 · M. Makhlouf, E. Radwan, O. Khorshed et al.

2

Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population

Study ↗ PDF ↗
PID
Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population

2015 · Yoshihiro Aiba, K. Yamazaki, N. Nishida et al.

3

C-X-C chemokine receptor type 5 gene polymorphisms are associated with non-Hodgkin lymphoma

Study ↗ PDF ↗
PID
C-X-C chemokine receptor type 5 gene polymorphisms are associated with non-Hodgkin lymphoma

2012 · Haihan Song, Danian Tong, Zhanshan Cha et al.

Curated Studies0 ▼

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

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Unused Studies0 ▼

No unused studies.