Genetics Research
rs61888800
Population Frequencies8
African
G 0.9295T 0.0705GG 0.866553GT/TG 0.125976TT 0.00747pop=5,890
African American
G 0.9284T 0.0716GG 0.864009GT/TG 0.128871TT 0.00712pop=5,618
African Others
G 0.952T 0.048GG 0.919118GT/TG 0.066176TT 0.014706pop=272
European
G 0.83815T 0.16185GG 0.714463GT/TG 0.247383TT 0.038154pop=17,770
Latin American 1
G 0.914T 0.086GG 0.83871GT/TG 0.150538TT 0.010753pop=186
Latin American 2
G 0.947T 0.053GG 0.900662GT/TG 0.092715TT 0.006623pop=604
Other
G 0.928T 0.072GG 0.871053GT/TG 0.113158TT 0.015789pop=760
Studies53
Unread Studies53 ▼
1
Pain has been a constant companion of humankind since the dawn of time. As a sensory perception, it is a complex, multidimensional phenomenon and an integral part of human life. It …
2
… The rs61888800 polymorphism contributes to better antidepressant effects with … plasticity Associated with MDD diagnosis; rs61888800 contributes to better antidepressant effects with …
3
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by …
4
… Novelty-seeking was associated with BDNF rs61888800 polymorphism in depression [36]. Kazantseva et al. (2014) found an association of a specific haplotype block within the BDNF …
5
Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), …
6
… They found that the T-carriers of BDNF rs61888800 exhibited … , and the correlation between rs61888800 T-carrying status … T-carriers of rs61888800 demonstrated lower expression of …
7
Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) …
8
… Furthermore, an untranslated region SNP (rs61888800) was associated with antidepressant response even after adjusting for a variety of factors including: sex, medication, age as well …
9
Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform …
10
Empathy refers to an individual's ability to experience the emotional and cognitive processes of another person during social interactions. Although many studies have …
11
Existe una cantidad creciente de evidencia que sugiere que la respuesta a ciertos medicamentos puede estar relacionada con la estructura genética de cada individuo. El …
12
There is a growing amount of evidence suggesting that specific medication responses can be linked to everyone’s genetic makeup. The advent of fast genomics and more …
13
There is a number of antidepressants (ADs) which prevent reabsorption of neurotransmitters in the body. Known together as reuptake inhibitors, they prevent the reuptake of one or …
14
… and two haplotypes in distinct blocks (one having Val66, and the other around exon VIIIhOne of the observed SNPs in the 5 untranslated region, rs61888800, was connected to …
15
Les études sur l’Animal et l’Homme montrent que le Récepteur Tyrosine-Kinase B (TRKB), principal récepteur du Brain Derived Neurotrophic Factor (BDNF), est impliqué …
16
Anxiety sensitivity (AS) is defined as the likelihood of interpreting anxiety-related bodily sensations as having potentially harmful effects on psychological and physical wellbeing. …
17
Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies involving large structural anomalies. Objective…
18
Childhood traumatic experiences and impulsive aggression are strong predictors of suicide ideation in youth. This study examines whether a gene panel previously associated with …
19
Patients with major depressive disorder (MDD) often stay on ineffective treatments for too long or switch/discontinue too early [1-3]. Even when taken for adequate duration, treatment …
20
According to the neurotrophic hypothesis of depression proposed two decades ago, the most important role in the pathogenesis of depressive disorders is played by abnormalities in …
21
O Transtorno de Déficit de Atenção/Hiperatividade (TDAH) representa um problema com relevante impacto social e econômico quando não tratado adequadamente, pois está …
22
В соответВ соответствии с нейротрофической гипотезой депрессии, предложенной два десятилетия назад, важнейшую роль в патогенезе депрессивных расстройств играют …
23
… We found the T-carriers of BDNF rs61888800 to show an increase in NS score. The outcome measured with MADRS score change also had an effect on this difference in the multi…
24
Depresi merupakan salah satu penyebab utama disabilitas secara global. Oleh karena itu, dibutuhkan suatu indikator awal yang dapat menilai risiko terjadinya depresi pada seseorang…
25
Antidepressant treatment alters brain-derived neurotrophic factor (BDNF) levels, but it is not well established whether BDNF can be used as a marker to prove the efficacy …
26
The scientific man does not aim at an immediate result. He does not expect that his advanced ideas will be readily taken up. His work is like that of the planter–for the future. His duty is …
27
… The SNP rs61888800 is shown to modulate the antidepressant response in Mexican … Such relationship has not been found among the population with SNP rs61888800 [Citation…
28
Converging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are …
29
We propose an extensive review of the literature about BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients. Five genome-…
30
Genetic factors may encourage or even cause the occurrence of mood disorders such as anxiety and/or depression. However, despite the significant amount of work and …
31
Major depressive disorder (MDD) is an emergent cause of personal and socioeconomic burden, since its high lifetime prevalence (16.2%) and the unsatisfying response rate of the …
32
Early reports of clinical utility are published. The current evidence base for antidepressant pharmacogenetics is, however, not yet empirically robust enough to inform routine prescribing …
33
Brain-derived neurotrophic factor (BDNF) is suggested to play a role in the aetiology of major depression and in the antidepressant response in patients with major depression. Several …
34
… In the present study, an association between BDNF polymorphisms rs11030101 and rs61888800 and change in the MADRS score during ECT was investigated. These polymorphisms …
35
… We used the 1000 Genomes Project Data set implemented in SNAP to retrieve LD informations of recently identified SNPs (eg rs61888800). We found only the BDNF SNP rs2030324, …
36
… We used the 1000 Genomes Project Data set implemented in SNAP to retrieve LD informations of recently identified SNPs (eg rs61888800). We found only the BDNF SNP rs2030324, …
37
Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …
38
Several lines of evidence, including psychopathological, neurobiological, pharmacological and epidemiological data, supported the association between Anorexia Nervosa (AN) and …
39
Signal transduction has been reported to be involved in antidepressant treatment outcomes; however, its mechanisms remain unclear. The aims of this study were to explore the …
40
… One recently reported 5’ untranslated region SNP, rs61888800, was associated with antidepressant response after adjusting for age, sex, medication, and baseline score on the 21-item …
41
Major depressive disorder is one of the most prevalent psychiatric disorders, and in spite of extensive ongoing research, we neither fully understand its etiopathological background, nor …
42
… Other SNPs in BDNF that have been associated with antidepressant-treatment outcome include rs61888800, and a haplotype of rs12273363, rs908867 and rs1491850 (Table 1) …
43
… One recently reported 5′ untranslated region SNP, rs61888800, was associated with antidepressant response after adjusting for age, sex, medication, and baseline score on the 21-…
44
Major depressive disorder is one of the most prevalent psychiatric disorders, and in spite of extensive ongoing research, we neither fully understand its etiopathological background, nor …
45
… The three other tested SNPs retrieved no significant association (rs1491850, rs1491851, rs61888800). Carriers of the C-allele of the rs10501087 (mean BPND: 5.47 소 0.96), the T-…
46
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has pivotal roles in neuronal survival, proliferation, and synaptic plasticity in the …
47
… Interestingly, a 5′-UTR intronic variant located near exon VIIh (SNP s12273539) and a 5′-UTR intronic variant located near exon V (SNP rs61888800) show the most significant …
48
Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. …
49
… Association analyses of 200 Mexican American MDD patients treated with desipramine or fluoxetine revealed that 1 SNP (rs61888800) in the 5' untranslated region was associated with …
50
… Interestingly, a 5′ untranslated region polymorphism (rs61888800) was associated with antidepressant response after adjusting for age, sex, medication, and baseline score on the 21-…
51
Allergic inflammation can trigger neuronal dysfunction and structural changes in the airways and the skin. Levels of brain‐derived neurotrophic factor (BDNF) are strongly …
52
… One recently reported 5′ untranslated region SNP, rs61888800, was associated with … needed to confirm the association of the rs61888800 SNP with antidepressant response. …
53
Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the …
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