Genetics Research
rs4659744
Gene: MTR — 5-Methyltetrahydrofolate-Homocysteine Methyltransferase
Chr 1:236896158
1q43
Intron Variant
Population Frequencies12
African
G 0.8069C 0.1931GG 0.652753GC/CG 0.308384CC 0.038863pop=5,558
African American
G 0.8054C 0.1946GG 0.650841GC/CG 0.309159CC 0.04pop=5,350
African Others
G 0.846C 0.154GG 0.701923GC/CG 0.288462CC 0.009615pop=208
Asian
G 0.588C 0.412GG 0.315789GC/CG 0.54386CC 0.140351pop=114
East Asian
G 0.59C 0.41GG 0.318182GC/CG 0.545455CC 0.136364pop=88
European
G 0.58934C 0.41066GG 0.346734GC/CG 0.485217CC 0.16805pop=17,114
Latin American 1
G 0.697C 0.303GG 0.473684GC/CG 0.447368CC 0.078947pop=228
Latin American 2
G 0.57C 0.43GG 0.351621GC/CG 0.436409CC 0.21197pop=802
Other
G 0.639C 0.361GG 0.405765GC/CG 0.465632CC 0.128603pop=902
Other Asian
G 0.58C 0.42GG 0.307692GC/CG 0.538462CC 0.153846pop=26
South Asian
G 0.696C 0.304GG 0.490196GC/CG 0.411765CC 0.098039pop=102
Studies5
Unread Studies5 ▼
1
The current study aimed to assess the effect of dietary calcium intake and possible interactions with calcium-sensing receptor (CASR) gene polymorphisms on colorectal cancer risk…
2
… Newly noted polymorphisms of DHFR (rs1677693 & rs1643659) have 30% decreased risk while MTR polymorphism (rs4659744) has 25% decreased risk of colon cancer only in the …
3
OBJECTIVE The goal of the present study was to assess the relationship between the genetic variability in six genes of methyl group (CH(3)) metabolism and the risk of obesity. METHODS Single nucleotide polymorphisms (SNP) were selected among the methylene-tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), cystationine betha-syntase (CBS), transcobalamin-II (TCN2) and paraoxonase-1 (PON1) genes. The associations between SNPs and the risk of obesity were assessed in a case-control study of obese and normal-weight adolescents (age: 14.9±1.2 years), and the relationship between SNPs and body fat markers (i.e., body mass index [BMI], percentage body fat [BF%] and waist circumference [WC]) in a cross-sectional study of 1 155 European adolescents (age: 14.8±1.4 years). Genotyping was performed on an Illumina system and plasma folate level was determined by immunoassay. RESULTS In the case-control study, there was no evidence for any association between SNPs of MTHFR, MTR, CBS, TCN2 and PON1 and obesity (all p values ≥0.08). In contrast, two SNPs of MTRR were associated with a higher (rs10520873, Odds Ratio: 1.68 [1.18-2.39]; p=0.004) or lower (rs1801394, 0.61 [0.42-0.87]; p=0.007) risk of obesity. In the cross-sectional sample, rs1801394 was associated with lower BMI (p=0.03) and lower waist circumference (p=0.02). However, after Bonferroni correction these associations were no longer significant. No other significant association or interaction between folate levels and SNPs were detected for anthropometric variables. CONCLUSION Our findings do not support an association between MTHFR, MTR, CBS, TCN2 and PON1 SNPs and obesity in adolescence. Further investigations are necessary to confirm the possible association between the rs1801394 variant of MTRR and obesity.
4
… These two linked (r 2 = 0.99) tagSNPs and one tagSNP in the MTR gene (rs4659744) were significantly associated with reduced colorectal cancer risk only among individuals not using …
5
Alleles major/minor Position GSR (%) rs3917538 G/A intron 5 100 rs662 A/G exon 6 100 rs3917550 G/A intron 7 100 rs854555 C/A intron 8 100 rs854552 A/G exon 9 100 rs854551 G/A …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.