Genetics Research
rs4148405
Population Frequencies12
African
T 0.57861G 0.42139TT 0.338022TG/GT 0.481181GG 0.180797pop=47,346
African American
T 0.57988G 0.42012TT 0.339432TG/GT 0.480895GG 0.179673pop=45,694
African Others
T 0.5436G 0.4564TT 0.299031TG/GT 0.489104GG 0.211864pop=1,652
Asian
T 0.7706G 0.2294TT 0.591064TG/GT 0.359135GG 0.049801pop=7,028
East Asian
T 0.7669G 0.2331TT 0.58319TG/GT 0.36741GG 0.0494pop=5,830
European
T 0.855223G 0.144777TT 0.731552TG/GT 0.247341GG 0.021107pop=385,654
Latin American 1
T 0.7542G 0.2458TT 0.575812TG/GT 0.356761GG 0.067428pop=5,606
Latin American 2
T 0.78871G 0.21129TT 0.6253TG/GT 0.326811GG 0.047889pop=11,652
Other
T 0.79212G 0.20788TT 0.632389TG/GT 0.319469GG 0.048142pop=11,300
Other Asian
T 0.7888G 0.2112TT 0.629382TG/GT 0.318865GG 0.051753pop=1,198
South Asian
T 0.834G 0.166TT 0.701471TG/GT 0.265074GG 0.033456pop=5,440
Studies13
Unread Studies13 ▼
1
… A lower DFS was reported with variant alleles of ABCC3 polymorphisms (rs4148405, rs1989983, … the previous findings of lower OS rates with the minor allele of ABCC3, rs4148405 [88]. …
2
Drug resistance is one of the main causes of chemotherapy failure. Although several factors are involved in cancer drug resistant, the exporter pumps overexpression that mediates the …
3
… The two other SNPs analyzed in our study, ABCC3 rs4148405 … This pharmacogenomics study identified rs4148405 and … that the association of ABCC3 rs4148405 with overall survival is …
4
Six‐month combination regimens could lead to serious hepatotoxicity, which may limit the clinical use of antituberculosis drugs. ABCC transporters are critical to the influx and efflux of …
5
Drug resistance and relapse are considered to be the major reasons for treatment failure in acute myeloid leukemia (AML). There is limited data on the role of ABC …
6
La leucemia mieloide crónica (LMC) se caracteriza por el rearreglo BCR-ABL1 sin embargo no se conocen losfactores genéticosque pueden influir en el desarrollo de la enfermedad y …
7
… The SNP rs4148405 was found to be associated with significantly shorter disease-free survival in AML patients, with the minor allele (G) being associated with shorter time to relapse …
8
… Nevertheless, variants of ABCC3 (rs4148405 and others) obtained significant associations with lower disease-free survival (DFS) in a Caucasian cohort of AML patients [Citation24], but …
9
… The SNP rs4148405 was found to be associated with significantly shorter disease free survival in AML patients, with the minor allele (G) being associated with shorter time to relapse. …
10
… The authors found similar relationships with rs4148405 in ABCC3, although while passing multiple testing correction in cohort 1 (p < 10e−06), it did not replicate in cohort 2. Additional …
11
… An intronic SNP (rs4148405) in ABCC3 was associated with a significantly shorter disease-free survival in adult acute myeloid leukemia (AML) patients treated with chemotherapy (…
12
… The analysis uncovered a SNP in the intronic region of ABCC3 (rs4148405), which was associated with a significantly shorter DFS in the primary cohort. A SNP in the GSTM1–GSTM5 …
13
… was the intronic variant in ABCC3, rs4148405 (HR=3.1, P=… suggest that the ABCC3 variant, rs4148405, is in a functional … that the minor allele of rs4148405 is associated with higher …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.