Genetics Research
rs3775442
Population Frequencies12
African
C 0.88319T 0.11681CC 0.78079CT/TC 0.20481TT 0.0144pop=55,554
African American
C 0.88397T 0.11603CC 0.782111CT/TC 0.203709TT 0.01418pop=53,596
African Others
C 0.8621T 0.1379CC 0.744637CT/TC 0.234934TT 0.020429pop=1,958
Asian
C 0.63223T 0.36777CC 0.395713CT/TC 0.473028TT 0.13126pop=11,382
East Asian
C 0.6285T 0.3715CC 0.386234CT/TC 0.484437TT 0.129329pop=9,124
European
C 0.983488T 0.016512CC 0.967339CT/TC 0.032299TT 0.000362pop=540,700
Latin American 1
C 0.9265T 0.0735CC 0.857818CT/TC 0.137456TT 0.004726pop=9,734
Latin American 2
C 0.83612T 0.16388CC 0.703541CT/TC 0.265153TT 0.031306pop=19,996
Other
C 0.90156T 0.09844CC 0.81961CT/TC 0.1639TT 0.01649pop=17,950
Other Asian
C 0.6475T 0.3525CC 0.434012CT/TC 0.426926TT 0.139061pop=2,258
South Asian
C 0.926T 0.074CC 0.860377CT/TC 0.131321TT 0.008302pop=7,950
Studies6
Unread Studies6 ▼
1
… In this study, significant differences in TT3 were found at two SNCA loci (rs3775442 and rs3775442). However, by searching the literature, there is no study on the relationship between …
2
Abstract Parkinson’s disease (PD) was reported to be connected with thyroid diseases clinically, which might be a critical clew to immune pathogenesis of PD. However, there was no further research to study the pathogenesis correlation between PD and thyroid diseases. In this study, except for investigating the difference in thyroid hormone between PD and the control group, we explored genetic correlation between thyroid and PD. We tried to find their shared molecular pathway by analyzing the effect of PD risk genes on thyroid function. Interestingly, most of those 12 meaningful SNPs we found could affect PD and thyroid function through immune mechanism, which is consistent with our original conjecture and provides significant evidence for the immune pathogenesis of PD.
3
The relative role of genetic and environmental factors in the pathogenesis of Parkinson’s disease (PD) has been the matter of investigation and debate, especially in the last 30 years. …
4
To date, nine Parkinson disease (PD) genome-wide association studies in North American, European and Asian populations have been published. The majority of studies …
5
Parkinson's disease (PD), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. …
6
We have used targeted high-throughput sequencing to characterize the 135kb SNCA locus in a large multi-national cohort of patients with PD, PDD, DLB and healthy controls. …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
No unused studies.