CHROMOSOME 10 ABCC2 10q24.2 GENE VIEW ABCC2 · 10q24.2 10q23 10q25 rs3740070 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs3740070 G / A · ABCC2 · 10q24.2 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ G 5′ 3′ G HETEROZYGOUS 5′ 3′ G 5′ 3′ A HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ A 5′ 3′ A G Guanine — reference allele A Adenine — variant allele genetics.jdge.cc

rs3740070

Gene: ABCC2 — ATP Binding Cassette Subfamily C Member 2 Chr 10:99831661 10q24.2 Synonymous Variant
NCBI ↗ Research Rabbit ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ ClinVar ↗ Varsome ↗ LOVD ↗

Population Frequencies11

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Total G 0.99905A 0.00095GG 0.99814GA/AG 0.001822AA 0.000039pop=618,126
African G 0.99996A 0.00004GG 0.99993GA/AG 0.00007AA 0pop=56,986
African American G 0.99996A 0.00004GG 0.999927GA/AG 0.000073AA 0pop=55,056
Asian G 0.97141A 0.02859GG 0.944602GA/AG 0.053611AA 0.001787pop=13,430
East Asian G 0.96644A 0.03356GG 0.935154GA/AG 0.062571AA 0.002275pop=10,548
European G 0.999692A 0.000308GG 0.999384GA/AG 0.000616AA 0pop=497,104
Latin American 1 G 0.9998A 0.0002GG 0.999517GA/AG 0.000483AA 0pop=8,280
Latin American 2 G 0.99985A 0.00015GG 0.999694GA/AG 0.000306AA 0pop=13,062
Other G 0.99801A 0.00199GG 0.996014GA/AG 0.003986AA 0pop=20,570
Other Asian G 0.9896A 0.0104GG 0.979181GA/AG 0.020819AA 0pop=2,882
South Asian G 0.9997A 0.0003GG 0.99931GA/AG 0.00069AA 0pop=8,694

Studies8

Unread Studies8
1
In pharmacogenetic studies, researchers explore how genetic variants impact individuals’ responses to drugs. Implementation of pharmacogenetic tests in clinical practice …
2
Um dos principais desafios da terapia antirretroviral é sua imprevisibilidade e variabilidade interindividual em seu desfecho. Investigou-se a contribuição de variáveis genéticas, …
3
… 有研究发现,阿德福韦酯相关的肾小管损伤与ABCC2基因(rs3740070) 22号外显子中c.2934G>A的 替换相关 [7] ,但由于野生型TCG和突变等位基因TCA都编码丝氨酸残基,所以这一替换是同义…
4
… Wei等 [8] 通过单核苷酸多态性分析发现ABCC2基因rs3740070高表达G/A基因型与ADV导致肾 损伤具有相关性.FGF23在磷代谢调节中存在多种作用 [9] :(1)抑制肾小管钠磷协同转运蛋白活性,…
5
Adefovir dipivoxil (ADV) is an oral bioavailable prodrug of adefovir, which is a phosphonate acyclic nucleotide analogue of adenosine monophosphate. It has antiviral effect, and has …
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要旨 [目的] Tenofovir disoproxil fumarate (TDF) は HIV 感染症, B 型肝炎の治療に広く用い られる核酸系逆転写酵素阻害薬 (nucleotide reverse transcriptase inhibitor: NRTI) だが, 腎障害の…
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Classification of the individuals” genotype data is important in various kinds of biomedical research. There are many sophisticated clustering algorithms, but most of them require some …
8
particular, is scarcely recognized as a sexually acquired Page 1 a diversity of sexual activities. Amebic infection, in particular, is scarcely recognized as a sexually acquired infection, …
Curated Studies0

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

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Unused Studies0

No unused studies.