Genetics Research
rs2275565
Gene: MTR — 5-Methyltetrahydrofolate-Homocysteine Methyltransferase
Chr 1:236885376
1q43
Intron Variant
Population Frequencies12
African
G 0.5306T 0.4694GG 0.281871GT/TG 0.497455TT 0.220673pop=46,766
African American
G 0.53266T 0.46734GG 0.28351GT/TG 0.498293TT 0.218197pop=45,106
African Others
G 0.4747T 0.5253GG 0.237349GT/TG 0.474699TT 0.287952pop=1,660
Asian
G 0.7892T 0.2108GG 0.631323GT/TG 0.315805TT 0.052872pop=6,998
East Asian
G 0.7925T 0.2075GG 0.635478GT/TG 0.314087TT 0.050435pop=5,750
European
G 0.787472T 0.212528GG 0.620393GT/TG 0.334158TT 0.045449pop=333,998
Latin American 1
G 0.7115T 0.2885GG 0.508235GT/TG 0.406536TT 0.085229pop=7,650
Latin American 2
G 0.78861T 0.21139GG 0.621846GT/TG 0.333528TT 0.044626pop=17,120
Other
G 0.75417T 0.24583GG 0.570869GT/TG 0.36661TT 0.062521pop=11,740
Other Asian
G 0.774T 0.226GG 0.612179GT/TG 0.323718TT 0.064103pop=1,248
South Asian
G 0.633T 0.367GG 0.392617GT/TG 0.479866TT 0.127517pop=596
Studies29
Unread Studies29 ▼
1
Homocysteine (Hcy) has been associated with an increased risk of diabetic nephropathy (DN) in patients, but there is still controversy. This study aims to investigate …
2
Hyperhomocysteinemia is a risk factor for ischemic stroke, but its role in hemorrhagic stroke remains unclear. Elevated homocysteine (Hcy) levels may promote endothelial …
3
Polycystic ovary syndrome (PCOS) is an endocrine disease attributed to multiple genetic variants and environmental factors. We aimed to find the causal association of …
4
Observational studies link elevated plasma homocysteine (Hcy) with vascular disease. Our aim was to assess the gender difference in the association between the plasma …
5
… , rs207454, rs11548, and rs3093556 had minimal evidence of binding or regulatory expression indicated by score 4, while three variants rs9686343, rs78594529, and rs2275565 had a …
6
Observational studies explore the association between vitamin B12 and obesity. However, causality is not reflected by such observations. We performed a bi-directional …
7
Association between homocysteine and nonalcoholic fatty liver disease: Mendelian randomisation study
Many observational studies explore the relationship between homocysteine (Hcy) and nonalcoholic fatty liver disease (NAFLD), whereas the causality of this association …
8
Observational studies explore the association between vitamin B12 and obesity. However, causality is not reflected by such observations. We performed a bi-directional …
9
Homocysteine, inversely related to folate and vitamin B12, is an independent risk factor for several age-related disorders. However, little is known about the association of homocysteine …
10
Genetic variations are associated with individual susceptibility to gastric cancer. Recently, polygenic risk score (PRS) models have been established based on genetic variants to predict …
11
Atrial fibrillation (AF) is one of the most prevalent rhythm disorders worldwide, with around 37.574 million cases around the globe (0.51 % global population). Different studies showed a …
12
Circulating concentrations of homocysteine and folate are inconsistently associated with the risk of nonalcoholic fatty liver disease (NAFLD) in observational studies. …
13
Limited studies have evaluated the associations of multiple metal exposures with homocysteine (Hcy) levels, which were independent risk factor for cardiovascular disease (CVD). …
14
Currently, it is unclear whether there is a causal association between genetically predicted plasma homocysteine (Hcy) levels and the risk of sarcopenia. We performed a …
15
The association between homocysteine and risk of multiple sclerosis (MS) remains unclear. We implemented a two-sample Mendelian randomization (MR) analysis to comprehensively …
16
Although several studies have shown an association between plasma homocysteine (Hcy) levels and atrial fibrillation (AF), the causality remains unclear. We …
17
Homocysteine (Hcy) is a toxic amino acid and hyperhomocysteinemia (HHcy) was reported to be associated with both cerebrovascular disease and neurodegenerative …
18
Observational studies have demonstrated the relations of homocysteine (HCY) with bone mineral density (BMD) and bone fracture risk, but yielding contradictory …
19
Blood homocysteine level and related vitamin levels are associated with various health outcomes. We aimed to assess causal effects of blood homocysteine, folate, and cobalamin on …
20
To assess the causality of potentially modifiable factors, including lifestyle, nutrients, lipids, anthropometric traits, and inflammatory factors of Parkinson's …
21
The association of plasma homocysteine level (PHL) with gastric cancer risk was reported in observational studies. However, the causality is challenging due to …
22
… In the sex-combined meta-analysis, we also observed evidence of association at MTR (rs2275565), which is a key enzyme for methionine biosynthesis. Nominal evidence of association …
23
The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the …
24
Cobalamin (Cbl) is an essential B vitamin involved in the normal functioning of the nervous system, the formation of key components of blood, DNA synthesis and methylation, and …
25
… , only MTR rs2275565 was significantly associated with disease risk (RR = 1.68, 95 % CI: 1.01, 2.86; LRT p = 0.049). However, none of the genotypes, including MTR rs2275565, were …
26
… Our results therefore suggest that chromosomal region around rs2275565 and rs1805087 is a candidate for harboring a causative variant for the survival effect by MTR. …
27
We have previously reported significant inverse associations between bladder cancer risk and dietary intake of vitamins B2, B6, B12, folate and protein in a hospital‐based bladder …
28
The I 2 statistic was used to present the heterogeneity among estimates for each SNPs in one analysis. The p value for the intercept in the MR-Egger regression was used present the …
29
To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer’s …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
No unused studies.