Genetics Research
rs2273504
Gene: CHRNA4 — Cholinergic Receptor Nicotinic Alpha 4 Subunit
Chr 20:63356709
20q13.33
Intron Variant
Population Frequencies12
African
G 0.85296A 0.14704GG 0.729919GA/AG 0.246078AA 0.024003pop=10,582
African American
G 0.85298A 0.14702GG 0.730286GA/AG 0.24539AA 0.024323pop=10,196
African Others
G 0.852A 0.148GG 0.720207GA/AG 0.264249AA 0.015544pop=386
Asian
G 0.5414A 0.4586GG 0.293436GA/AG 0.495963AA 0.2106pop=5,698
East Asian
G 0.539A 0.461GG 0.287993GA/AG 0.502099AA 0.209908pop=4,764
European
G 0.830932A 0.169068GG 0.690177GA/AG 0.281509AA 0.028314pop=154,766
Latin American 1
G 0.853A 0.147GG 0.732759GA/AG 0.241379AA 0.025862pop=464
Latin American 2
G 0.7534A 0.2466GG 0.581267GA/AG 0.344353AA 0.07438pop=2,904
Other
G 0.8079A 0.1921GG 0.663897GA/AG 0.288089AA 0.048015pop=2,166
Other Asian
G 0.554A 0.446GG 0.321199GA/AG 0.464668AA 0.214133pop=934
South Asian
G 0.901A 0.099GG 0.807692GA/AG 0.186813AA 0.005495pop=364
Studies42
Unread Studies42 ▼
1
Dysfunction in ion channels or processes involved in maintaining ionic homeostasis is thought to lower the threshold for cortical spreading depression (CSD), and plays a role in …
2
Genetics plays a significant role in smoking behaviours and abstinence. In this genetics sub-study, we evaluated treatment-seeking Caucasian smokers (n= 374) receiving bupropion (n…
3
The study aimed to discover some variables influencing the risk of nicotine dependence in the Anatolian population. We examined 10 candidate genes and analysed 10 single …
4
… A mild association trend was also observed between the rs2273504 G allele of the CHRNA4 gene and the number of CPD ( P < .05), and to a lesser extent with AO ( P = .06). …
5
… Greater percent decreases in β 2 *-nAChR availability in smokers over prolonged abstinence were found in homozygotes of CHRNA4 SNP rs2273502 and rs2273504 compared to …
6
The aim of this study is to determine association between α-4 subunit of nicotinic acetylcholine receptor single nucleotide polymorphism (rs2236196 and rs2273502 loci) and …
7
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Nicotine's rewarding effects are mediated through distinct subunits of nAChRs, encoded by different nicotinic cholinergic receptor (CHRN) genes and expressed in discrete regions in …
8
This chapter summarizes genetic factors that contribute to variation in nicotine Nicotine pharmacokinetics and nicotine’s pharmacological action in the central nervous system (CNS), …
9
A grande variabilidade individual em resposta a fármacos antitabagismo sugere que tratamentos específicos podem ser mais efetivos em determinados subgrupos de …
10
The large individual variability in response to drugs for smoking cessation suggests that specific treatments can be more effective in particular subgroups of smokers. In the …
11
A major milestone of child development is the acquisition and use of speech and language. Communication disorders, including speech sound disorder ( SSD ), can impair a child's …
12
Nicotine addiction is a complex and multifactorial disease affecting the central nervous system and consists of a set of characteristic symptoms and signs. Objective The …
13
Cigarette smoke is a strong risk factor for obesity and cardiovascular disease. The effect of genetic variants involved in nicotine metabolism on obesity or body composition has not been …
14
Atherosclerosis is the underlying cause of cardiovascular disease, the leading cause of morbidity and mortality in all American populations, including American Indians. …
15
We investigated whether nicotine dependence affects these endophenotypes in Japanese schizophrenia patients and whether alpha4 and beta2 subunits of neuronal …
16
Recent research strongly suggests that a specific genetic background influences smoking behaviour and may also determine the efficacy of pharmacotherapies used for smoking …
17
Smoking behaviour is a major public health problem worldwide. Several sources have confirmed the implication of genomic factors in smoking behaviour. These factors …
18
Public Health Genomics (PHG) is the field of translating genome-based information and technologies into policies and healthcare. Among its many tasks, PHG provides also new …
19
The α4β2 nicotinic receptor is of central importance in tobacco dependence, while the homomeric α7 receptor may also play a role. In this candidate gene study, we …
20
In 1988 the US Surgeon General's report stated that tobacco use, in any form, is addicting as a result of its nicotine content and defined the processes determining tobacco addiction as" …
21
La presente tesis plantea la hipótesis de la existencia de una asociación de las variaciones genéticas que contiene los genes CHRNA3, CHRNA5 y CHRNB4 y varios fenotipos de …
22
Large-scale population studies have proved that genetic factors contribute to individual differences in smoking behavior. Genes responsible for nicotine's pharmacokinetics and …
23
Nicotine dependence (ND) is one of the world's leading causes of preventable death. Nicotine addiction and other forms of drug addiction continue to be significant public health …
24
After the Smoking Ordinance enacted in HK since 1/2007, shifting of smoking from outdoor to home was found, home becomes a major source of secondhand smoke (…
25
… In addition, nAChR α4 subunit (CHRNA4) rs2273504 showed the strongest association with ND (G/A or G/G, 72.4%, n=330; A/A, 45.87%, n=83; P <0.001, OR=3.11, 95%CI=1.90-5.10). …
26
… For the intronic rs2273504 typed in R1 and R2, relevant associations emerged neither in the Fagerstrom nor in the case–control analyses, although the small effect estimates in both …
27
Nicotine dependence (ND), a major public health challenge, is a complex, multifactorial behavior, in which both genetic and environmental factors have a role. Brain nicotinic …
28
Substance addiction is a complex chronic brain disorder, characterized by neurobiological changes leading to compulsive drug seeking and taking. Although environmental factors …
29
Tobacco smoking continues to be a leading cause of preventable death. Recent research has underscored the important role of specific cholinergic nicotinic receptor subunit (CHRN) …
30
The mesolimbic system is thought to be involved in the reinforcing action of many addictive drugs and the release of dopamine modulated by neuronal nicotine cholinergic receptors (…
31
… Two SNPs in CHRNA4 were associated in the EA sample (rs2273504 and rs1044396) and in the AA sample (rs3877137 and rs2236196). Also haplotype analysis showed significant …
32
Extensive epidemiological data indicate that vulnerabilities to nicotine dependence (ND) are influenced by genes, environmental factors, and their interactions. …
33
… that for CHRNA4 SNPs rs2273502 and rs2273504 there were no significant differences across … of this ANKK1 SNP with the CHRNA4 SNPs rs2273504 and rs2236196, as evidence by …
34
… with all three indices of nicotine dependence examined (smoking quantity (SQ), heaviness of smoking index (HSI) and FTND) in African American women, another SNP (rs2273504) …
35
Previous work suggests that young women who smoke cigarettes regularly, or did so in the past, manifest a neurocognitive profile that is characterized by small but significant …
36
People who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (…
37
The determination of gene-by-gene and gene-by-environment interactions has long been one of the greatest challenges in genetics. The traditional methods are typically inadequate …
38
Current smoking cessation treatments are not optimal as the long-term abstinence rates are low. Nicotine replacement therapy and bupropion are the only pharmacotherapies widely …
39
… rs3787137 and rs2236196 in the AA samples and rs2273504 and rs1044396 in the EA samples with … In contrast, SNPs rs2273504 and rs2236196 or SNP rs2273504 were significantly …
40
Nicotine is the major addictive substance in cigarettes, and genes involved in sensing nicotine are logical candidates for vulnerability to nicotine addiction. We studied six single-…
41
Tezimin tüm aşamalarında yanımda olan ve desteğini esirgemeyen değerli arkadaşım Arş. Gör. Mehmet Tuğhan KIZILTUĞ'a, karşılaştığım zorluklarda yol gösterici olan Arş. Gör. …
42
Smoking cessation is extremely important to prevent the development of the serious diseases, such as COPD and cancers. Absorbed nicotine through smoking into the body is mainly …
Curated Studies0 ▼
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