Genetics Research
rs12979860
Population Frequencies12
African
C 0.41692T 0.58308CC 0.179024CT/TC 0.475792TT 0.345185pop=30,320
African American
C 0.41819T 0.58181CC 0.180166CT/TC 0.476055TT 0.34378pop=29,484
African Others
C 0.372T 0.628CC 0.138756CT/TC 0.466507TT 0.394737pop=836
Asian
C 0.9191T 0.0809CC 0.844432CT/TC 0.149254TT 0.006315pop=3,484
East Asian
C 0.9278T 0.0722CC 0.859447CT/TC 0.136713TT 0.00384pop=2,604
European
C 0.688568T 0.311432CC 0.475947CT/TC 0.425241TT 0.098811pop=177,692
Latin American 1
C 0.5756T 0.4244CC 0.337808CT/TC 0.475551TT 0.186641pop=6,258
Latin American 2
C 0.59813T 0.40187CC 0.361219CT/TC 0.473826TT 0.164955pop=11,882
Other
C 0.6462T 0.3538CC 0.429093CT/TC 0.434148TT 0.136759pop=7,122
Other Asian
C 0.893T 0.107CC 0.8CT/TC 0.186364TT 0.013636pop=880
South Asian
C 0.759T 0.241CC 0.576017CT/TC 0.366167TT 0.057816pop=934
Studies20
Unread Studies20 ▼
1
Introduction. The study of the role of cytokines in cellular interactions in liver diseases is currently given great importance. However, studies in this area in patients with Opisthorchis felineus (O. felineus) invasion are still limited. Aim . To study the relationship between laboratory and instrumental manifestations of pathology with polymorphisms of the genes IFNG (rs2069705) and IL28b (rs12979860) in patients with O. felineus invasion. Materials and methods . A total of 360 p…
2
Мета. Вивчити можливий зв’язок поліморфізмів С/Т rs12979860 гена IFNL4 зі схильністю до розвитку герпетичного кератиту (ГК) у осіб після перенесеного COVID-19. Матеріал та методи. Всього проаналізовано 50 очей у 50 хворих у загальній групі пацієнтів із ГК (n=50), що розвинувся після перенесеної СOVID-19 інфекції. Група обстеження включала: а) хворі з первинним ГК після перенесеного СOVID-19 (n=16) та б) хворі з рецидивом ГК після перенесеного СOVID-19 (n=34). Генотип пацієнта за поліморфізмом ге…
3
Interferon-λ3 rs12979860 polymorphism and early-life RSV-bronchiolitis are associated with persistent asthma in male children: a 4-year prospective follow-up study.
4
This research addresses IL-28B gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’s impact on immunity, this study seeks biomarkers for early diagnosis and intervention. A systematic search met inclusion criteria, such as open access bibliographic and experimental studies published in English between…
5
Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality among allogeneic stem cell transplant (allo-SCT) recipients especially in pediatric leukemia patients. IFN-λ family: interleukin (IL)-28A, -28B, and -29 and IFN-λ4. All have antiviral properties similar to IFN-α. In vivo, IFN-λs are mostly secreted by dendritic cells (DC) and macrophages. IL-28B signals through a heterodimeric receptor consisting of IL-28R1 chains and IL-10Rβ, hence inducing an antiviral state. It has b…
6
treat-Objectives: Interleukin-28B (IL-28B) gene polymorphisms play an important role in response prediction of direct-acting antivirals (DAAs) treatment, including Sofosbuvir and Daclatasvir with or without Ribavirin
7
Background and objective The allelic discrimination of IFNL3-(rs12979860 C > T) polymorphism reveals ambiguous associations with the effectiveness of oral HCV treatment. Solitary intra peripheral-blood-mononuclear-cells (PBMCs) HCV-RNA antisense-strands are independently detected in naïve and experienced cases regardless of viremia or hepatic-parenchymal alterations. We examined the frequencies of IFNL3-genetic variants with chronic-HCV-induced liver changes during the sustained virologic respon…
8
Pulmonary fibrosis (PF) is the last phase of interstitial lung diseases (ILDs), which are a collection of pulmonary illnesses marked by parenchymal remodeling and scarring. Treatment can only halt the functional decline of the lung, raising the necessity of identifying the basic processes implicated in lung fibrogenesis. The Interferon lambda-3 (IFNL3) gene variant, rs12979860, was determined to be related to an elevated risk of fibrosis in different organs, but the mechanism through which it me…
9
Distribution of Genotypes for the rs12979860 Polymorphism of the IFNL Gene among Children with COVID-19 in Ukraine
10
OBJECTIVE The purpose of this study was to evaluate the relationship of IL28B rs12979860 and rs8099917 polymorphisms with the clinical, histological, and virological outcomes of patients with chronic hepatitis B (CHB) also the treatment responses of patients who received Nucleos(t)ide analogs (NAs) therapy. METHODS This study included 152 CHB patients who were underwent liver parenchymal biopsy. The IL28B rs12979860 and rs8099917 polymorphism were genotyped using the TaqMan assay. RESULTS The IL…
11
Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have suffered a positive selection pressure throughout the evolutionary history of the genus Homo. An intronic variant within the IFNλ4 locus (rs12979860, T˃C) emerged as one of the main gene determinants of the response to HCV and other viruses. The rs12979860-C allele has a differen…
12
IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON- λ 4 RS12979860 POLYMORPHISM IN A GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA
13
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. The association of interleukin 28B (IL-28B) polymorphisms and HCC has been investigated in several populations. However, the findings are controversial. This study aimed to address the association between IL-28B polymorphisms (rs 8099917 T/G, rs12979860 C/T, rs12980275 A/G) and the risk of HCC in an Iranian population. METHODS: We have evaluated the association between IL-28B polymorphisms (rs 8099917 T/G, r…
14
Introduction: The natural course of Hepatitis C Virus (HCV) infection is influenced by a number of host and viral variables. Interleukin 28B (IL28B) is a kind of interleukin. A Single Nucleotide Polymorphism (SNP) designated as rs12979860 was reported to predict viral clearance with and without treatment. Subjects with the GG (favourable) IL28B rs12979860 genotype were more likely to clear the infection spontaneously and respond well to therapy. These findings imply that people who have the “fav…
15
BACKGROUND Hepatitis C virus (HCV) infection is a public health concern worldwide. Several factors, including genetic polymorphisms, may be evolved in the progression of HCV infection to liver diseases. Interferon lambdas (IFNLs) modulate the immune response during viral infections. IFNLs induce antiviral activity, interfering in the viral replication by promoting the expression of several genes that regulate immunological functions. The interferon lambda-4 (IFNL4) rs12979860 polymorphism, which…
16
Background Autoimmune hepatitis (AIH) is a relatively rare chronic liver disease of unknown etiology. The genetic background affects susceptibility, clinical phenotype, and prognosis. The programmed cell death-1 rs11568821 polymorphism (PD1.3) has been associated with susceptibility to autoimmune diseases. The interleukin-28B (IL28B) rs12979860 polymorphism has been associated with steatosis, inflammation, and fibrosis in liver diseases. Aim Our aim was to investigate for the first time the inci…
17
Interferon-λ rs12979860 genotype association with liver fibrosis in chronic hepatitis C (CHC) patients in the Pakistani population
18
Impact of interleukin 28B (IL28B) rs12979860 polymorphism on response to direct-acting antivirals agents in HCV genotype 4-infected patients is under investigation. Zinc may have an advantage in improvement of liver damage and treatment outcome. We aimed to evaluate IL28B polymorphism and zinc administration impact on patient response to treatment and amelioration of liver fibrosis. Three hundred patients on anti-HCV treatments were equally categorized into patients treated with dual therapy (so…
19
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provides a critical host-immunological challenge. Aim: We explore the effect of host-genetic variation in interferon-lambda-3 rs12979860, Tolloid Like–1 (TLL1) rs17047200 and Discoidin domain receptor 1(DDR1) rs4618569 on host response to respiratory viral infections and disease severity that may probe the mechanistic approach of allelic variation in virus-induced inflammatory responses. Methods: 141 COVID-19 posi…
20
Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex etiology. Various genetic factors are associated with susceptibility to developing SLE and contribute to its onset and progression. Different single-nucleotide polymorphisms (SNPs) have been associated with SLE in several populations. The rs12979860 SNP in interferon lambda 3/4 (IFNλ3/4) is significantly associated with SLE susceptibility in patients negative for nephritis in Taiwanese people, and interferon-stimulated ge…
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