Genetics Research
rs11866328
Gene: GRIN2A — Glutamate Ionotropic Receptor NMDA Type Subunit 2A
Chr 16:9768699
16p13.2
Intron Variant
Population Frequencies12
African
G 0.60631T 0.39369GG 0.36835GT/TG 0.475921TT 0.155729pop=42,818
African American
G 0.60607T 0.39393GG 0.367924GT/TG 0.476299TT 0.155777pop=41,264
African Others
G 0.6126T 0.3874GG 0.379665GT/TG 0.465894TT 0.15444pop=1,554
Asian
G 0.81602T 0.18398GG 0.66601GT/TG 0.30003TT 0.03396pop=13,192
East Asian
G 0.81849T 0.18151GG 0.669994GT/TG 0.296986TT 0.03302pop=10,418
European
G 0.579534T 0.420466GG 0.336522GT/TG 0.486024TT 0.177453pop=384,236
Latin American 1
G 0.6054T 0.3946GG 0.369658GT/TG 0.47151TT 0.158832pop=5,616
Latin American 2
G 0.7022T 0.2978GG 0.493921GT/TG 0.416564TT 0.089515pop=11,350
Other
G 0.64051T 0.35949GG 0.411093GT/TG 0.458829TT 0.130077pop=16,298
Other Asian
G 0.8068T 0.1932GG 0.651045GT/TG 0.311464TT 0.037491pop=2,774
South Asian
G 0.743T 0.257GG 0.556695GT/TG 0.37257TT 0.070734pop=3,704
Studies41
Unread Studies41 ▼
1
Dopamine receptor inhibition underlies both the therapeutic and adverse effects of antipsychotics, but the mechanisms modulating these effects in patients with schizophrenia remain …
2
The polymorphisms of IFNL3 associated with the outcomes of primary HBV infection remains controversial, the susceptibility has not been investigated across cohorts. So two cohorts, …
3
Gene-environment interactions increase psychosis risk (Gayer-Anderson et al. Soc Psychiatry Psychiatr Epidemiol 2020; 55(5):645-657). However, identifying the genetic …
4
Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, …
5
Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, …
6
The vulnerability-stress-inflammation model is a well-known psychopathological model in patients with psychosis. It implies an imbalance of the microglia activation (M1/M2 …
7
The dopamine, serotonin and glutamate systems are jointly involved in the pathogenesis and pharmacotherapy of schizophrenia. We formulated a hypothesis that polymorphic variants …
8
Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) are progressions affected by genetic predispositions, and persistent hepatitis B virus infection also demonstrates …
9
Цель. Сравнить Частоты Генотипов Полиморфных Вариантов Генов Grin2a И Grin2b В Группах Больных Шизофренией С Аддиктивным Поведением (Злоупотребление …
10
Clinical Applications of Immunogenetics: Immunogenetics: A Molecular and Clinical Overview, Volume II provides readers with an exclusive, updated overview of scientific knowledge, …
11
Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the …
12
This study aimed to explore the relationship between CCNE1 gene single nucleotide polymorphisms (SNP rs1406 and rs3218038) and the incidence of hepatitis B virus-related …
13
Genome-wide association studies have been performed to identify common genetic variants associated with hepatitis B (HB). However, little is known about copy number variations (…
14
The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by …
15
The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide …
16
Chronic hepatitis B (CHB) is a precursor to liver cirrhosis and hepatocellular carcinoma, caused by a Hepatitis B viral infection. Genome-wide association studies (GWASs) have been …
17
… In addition, rs11866328 at GRIN2A has been reported to be associated with the disease progression of chronic HBV infection (18). In this study, the at-risk allele of rs11866328 was …
18
… Genotype-phenotype association analyses performed on 10 SNPs along with the discrete attributes revealed rs11866328 (C>A) and rs12325652 (A>G) to be positively correlated with …
19
Chronic hepatitis B (CHB) is the most common chronic liver disease resulting from viral infection and has become a serious threat to human health. Each year, about 1.2 million people …
20
An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined …
21
Infectious diseases are among the leading causes of human morbidity and mortality, with the greatest burden felt in the pediatric population. For any infectious disease, only a fraction of …
22
More than a million childhood diarrhoeal episodes occur worldwide each year, and in developed countries a considerable part of them are caused by viral infections. In this study, we …
23
We have previously identified 8 SNPs in Han Chinese HBV carriers that are associated with disease progression. Although not well studied, genetic factors may also play a significant …
24
Belgium has seen major changes in its tax-benefit system over the past twenty years. These changes have, to a large extent, co-determined the evolution of disposable incomes of …
25
… The variant rs11866328 (G/T), located in the glutamate receptor ionotropic N-methyl D-aspartate 2A (GRIN2A) gene, showed a significant association with disease progression (Table 1)…
26
Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of hepatocellular carcinoma (HCC) or chronic hepatitis B …
27
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (…
28
… A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection.Viral Immunol2011;…
29
Advances in genomics are contributing to the development of more effective, personalized approaches to the prevention and treatment of infectious diseases. Genetic sequencing …
30
… 16p GRIN2A rs11866328 Chinese 1944 progressed carriers/854 asymptomatic carriers … A genome-wide association study with DNA pooling identifies the variant rs11866328 in the …
31
Vaccines are the most cost effective public health measure for preventing viral infection and limiting epidemic spread within susceptible populations. However, the efficacy of current …
32
Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is more characteristic of anoxic encephalopathy than of other types of anoxia. Those who have the same …
33
The glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene that encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor was recently shown to be involved in the …
34
… Hum Mol Genet 20 ; 3884―3892 : 2011 24)Liu L, Li J, Yao J, et al : A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that …
35
Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal …
36
Host genetics play a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. To identify novel susceptibility loci to HBV progression, we carried out a genome-wide …
37
… We revealed the important role of SNP rs11866328 on the gene … rs11866328 may affect an individual's susceptibility to HBV progression. Our research indicates that SNP rs11866328 …
38
A genome-wide association study with DNA pooling identifies the variant study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease …
39
A doença de Chagas é causada pelo protozoário Trypanosoma cruzi e atinge cerca de 12 milhões de pessoas no continente americano, a forma clássica de transmissão ocorre por …
40
KAWAMATA, CEM Identification of possible genes related to Trypanosoma cruzi infection in the human host. 2011. 125 p.(Ph. D. Thesis Biology of the interactions between Hosts and …
41
Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
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Unused Studies0 ▼
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