Genetics Research
rs11717195
Population Frequencies12
African
T 0.88482C 0.11518TT 0.782536TC/CT 0.204561CC 0.012903pop=35,960
African American
T 0.88362C 0.11638TT 0.780455TC/CT 0.206337CC 0.013207pop=34,526
African Others
T 0.9135C 0.0865TT 0.832636TC/CT 0.161785CC 0.005579pop=1,434
Asian
T 0.9923C 0.0077TT 0.984646TC/CT 0.015354CC 0pop=8,988
East Asian
T 0.9978C 0.0022TT 0.995551TC/CT 0.004449CC 0pop=7,192
European
T 0.77449C 0.22551TT 0.59941TC/CT 0.35016CC 0.05043pop=199,486
Latin American 1
T 0.8028C 0.1972TT 0.633205TC/CT 0.339217CC 0.027579pop=3,626
Latin American 2
T 0.7121C 0.2879TT 0.514071TC/CT 0.396133CC 0.089796pop=9,310
Other
T 0.8044C 0.1956TT 0.648985TC/CT 0.310886CC 0.040129pop=4,336
Other Asian
T 0.9705C 0.0295TT 0.94098TC/CT 0.05902CC 0pop=1,796
South Asian
T 0.7774C 0.2226TT 0.601329TC/CT 0.352159CC 0.046512pop=1,204
Studies47
Unread Studies47 ▼
1
Diagnostic testing is fundamental to modern medicine, enabling accurate disease detection, monitoring, and prevention. Traditional venous blood collection, while effective, presents …
2
Type 2 diabetes mellitus (T2DM) is a significant global health challenge, with increasing morbidity and mortality, particularly in developing countries. Understanding the …
3
While AI has automated bioinformatic workflows, biological interpretation remains fragmented and often disconnected from mechanistic insights. Existing AI is bifurcated between …
4
The Impact of Maternal Obesity and Diabetes on the Development of Congenital Heart Defects (CHDs) in Offspring: A Narrative Review
5
Insulin resistance (IR) is a metabolic disorder characterized by an impaired response to insulin. This condition is associated with excess adiposity and metabolic inflammation, …
6
Mediante los estudios de escaneo completo del genoma del Genome-Wide Asso-ciation Study (GWAS) se han identificado y validado más de 80 señales asociadas al fenotipo de …
7
The prevalence of cardiometabolic diseases has increased in Latin American and the Caribbean populations (LACP). To identify gene-lifestyle interactions that modify the …
8
… Several previous GWASs demonstrated that SNPs (for example rs11708067 and rs11717195) in ADCY5 may be associated with type 2 diabetes [101,105,106,107]. Hodson et al. …
9
Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied …
10
This research aimed at determining the causal relationship between type 2 diabetes mellitus (T2DM) and ovarian cancer using two-sample Mendelian randomization technique. …
11
Observational studies have associated lifestyle, dietary, adiposity, biochemical and clinical measures with heart failure. Whether the associations are …
12
This thesis evaluates the effects of ancestry and admixture on the utility and generalizability of polygenic scores for risk prediction and stratification in diverse populations in the US and …
13
O diabetes mellitus tipo 2 (DM2) caracteriza-se por uma hiperglicemia, devido a uma deficiência de insulina causada por disfunção das células β pancreáticas, que pode ser …
14
The genetic information of modern man, or Homo sapiens, is kept along 23 pairs of chromosomes located in the nucleus of every diploid cell. Diploid is understood as the cells that have …
15
The 1000 Genomes Project evidenced the need to study the genetic variability of various populations of the world. The human genome has common or rare variations greater than 1% …
16
We tested the hypothesis that the cumulative effects of common genetic variants related to elevated fasting glucose are collectively associated with oxidative stress. Using 25 single …
17
The development of recombinant DNA and other molecular techniques in the 1970s have profoundly altered the practice of human biology. Since then, new findings in genetics and …
18
Type 1 diabetes (T1D) is a common complex metabolic disease characterized by the autoimmune destruction of insulin-producing β cells of the pancreatic islets. Due to a …
19
Type‐2 diabetes (T2D) is associated in observational studies with both higher bone mineral density (BMD) and higher fracture risk for given BMD. These relationships may however be …
20
Gestational diabetes (GDM) and type 2 diabetes (T2DM) share part of pathomechanism and several T2DM susceptibility genes are demonstrated to be associated with GDM. No …
21
… rs11717195 and rs11708067 exhibit strong linkage disequilibrium (LD) with each other (r 2 ≥0.938, 1000 Genomes phase 3) in individuals of European, East Asian, and South Asian …
22
Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. …
23
Úvod: Diabetes mellitus druhého typu (T2DM) je celosvětově rozšířené civilizační onemocnění, jehož prevalence neustále narůstá. Ačkoli je pravděpodobnost jeho manifestace …
24
Diabetes mellitus je chronické metabolické onemocnění, které způsobují environmentální a genetické faktory. Toto onemocnění je charakteristické zvýšenou hladinou glukózy v krvi. …
25
The burden of Type 2 diabetes is alarmingly high in South Asia, a region that has many genetically diverse ethnic populations. Genome‐wide association studies ( GWAS ) …
26
Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, …
27
The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual's …
28
Cardiovascular disease (CVD) and type 2 diabetes (T2D) are major public health burdens in the United States. Metabolic risk factors for these diseases include increased triglyceride …
29
T2D is a complex disease characterized by a high prevalence and incidence worldwide, and recognizes genetic and non-genetic (environmental) risk factors as underlying determinants…
30
The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual’s …
31
The increasing burden of T2D is a global cause of concern. However in Africa where the countries are ill equipped to manage this pandemic, the prevalence of T2D will …
32
Several challenges face bioinformaticians on a regular basis. One of these is unsupervised clustering. In RNA sequencing (RNAseq), this may come in the form of blindly sequencing …
33
A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have …
34
Type 2 Diabetes (T2D) is a chronic disease arising from the development of insulin absence or resistance within the body, and a complex interplay of environmental and genetic factors. …
35
… Of the individual loci considered in our study, only ADCY5 (rs11717195) showed an interaction with BMI significant below the Bonferroni-adjusted level. ADCY5 was also one of highest-…
36
… Of the individual loci considered in our study, only ADCY5 (rs11717195) showed an interaction with BMI significant below the Bonferroni-adjusted level. ADCY5 was also one of highest-…
37
Epidemiological evidence shows that diabetes is associated with a reduced risk of prostate cancer. The objective of this study was to identify genes that may contribute to both …
38
We aimed to define the effects of peroxisomal proliferator-activated receptor γ (PPARγ) and PPARα agonist mono and combination therapy on adipose tissue and skeletal …
39
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …
40
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide …
41
The Cardiovascular Health Study (CHS) research reported in this article was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, …
42
Genome-wide association studies (GWAS) have successfully detected thousands of genetic variants associated with various traits and diseases [1–4]. The vast majority of genetic …
43
For this example, we will found out the mode of inheritance of the genetic disorder ataxia telangiectasia and the gene associated with this disorder, genetic tests, and labs in US offering …
44
The burden of type-2 diabetes is alarmingly high in South Asia, a region that has many genetically diverse ethnic populations. Genome-wide association studies (GWAS) …
45
The rate at which diabetes progresses following diagnosis of type 2 diabetes is highly variable between individuals. Research Design and Methods: We studied 5250 patients …
46
La obesidad y la diabetes mellitus tipo 2 (DM2) son enfermedades representativas de la alteración del metabolismo. Esta investigación comparó factores de riesgo a obesidad y DM2 …
47
Ample observational evidence indicates that patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions, in particular cardiovascular …
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.