CHROMOSOME 11 DRD2 11q23.2 GENE VIEW DRD2 · 11q23.2 11q22 11q24 rs1124493 — ~70,000 base pairs in the gene — ~14,000 uncommon variants · <1% of humans have them — ~1,000 common variants · >1% carry the alternate allele ALLELE STATE rs1124493 T / G · DRD2 · 11q23.2 HOMOZYGOUS WILD TYPE (DOMINANT) 5′ 3′ T 5′ 3′ T HETEROZYGOUS 5′ 3′ T 5′ 3′ G HOMOZYGOUS ALTERNATE (RECESSIVE) 5′ 3′ G 5′ 3′ G T Thymine — reference allele G Guanine — variant allele genetics.jdge.cc

rs1124493

Gene: DRD2 — Dopamine Receptor D2 Chr 11:113411573 11q23.2 Intron Variant
NCBI ↗ GeneCards ↗ Open Targets ↗ gnomAD ↗ OMIM ↗ ClinVar ↗ Varsome ↗ LOVD ↗

Population Frequencies12

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Total T 0.359467G 0.640533TT 0.143288TG/GT 0.432357GG 0.424355pop=263,162
African T 0.63096G 0.36904TT 0.39801TG/GT 0.465892GG 0.136098pop=35,974
African American T 0.62832G 0.37168TT 0.394117TG/GT 0.468412GG 0.137472pop=34,538
African Others T 0.6943G 0.3057TT 0.491643TG/GT 0.405292GG 0.103064pop=1,436
Asian T 0.5458G 0.4542TT 0.300423TG/GT 0.490772GG 0.208806pop=8,994
East Asian T 0.5581G 0.4419TT 0.312587TG/GT 0.49097GG 0.196443pop=7,198
European T 0.30164G 0.69836TT 0.09102TG/GT 0.421239GG 0.487741pop=199,692
Latin American 1 T 0.4259G 0.5741TT 0.187431TG/GT 0.476847GG 0.335722pop=3,628
Latin American 2 T 0.329G 0.671TT 0.107227TG/GT 0.443491GG 0.449282pop=9,326
Other T 0.391G 0.609TT 0.152995TG/GT 0.476037GG 0.370968pop=4,340
Other Asian T 0.4967G 0.5033TT 0.25167TG/GT 0.489978GG 0.258352pop=1,796
South Asian T 0.3692G 0.6308TT 0.139073TG/GT 0.460265GG 0.400662pop=1,208

Studies17

Unread Studies17
1
Exercise addiction is a behavior that may dysregulate athletic performance, and social and professional interactions of athletes. Whereas environmental factors including training …
2
Combination therapies for cystic fibrosis (CF) have shown promise for improving survival but pose challenges in optimizing complex regimens for people with CF (PwCF). With …
3
Chemotherapy-induced nausea and vomiting (CINV) remains a common adverse effect for children with cancer. In children, chemotherapy emetogenicity and patient factors such as …
4
Психические расстройства и болезни зависимости относятся к распространенным и тяжелым заболеваниям. Не менее драматичной является ситуация и в области …
5
Are you currently taking any of these medications? If so please tick the YES column next the medication and indicate the amount of medication your child takes daily, in milligrams (mg…
6
The antipsychotic action of haloperidol is due to the blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with …
7
Dyskinesia is a known side-effect of the treatment of Parkinson's Disease (PD). We examined the influence of haplotypes in three dopamine receptors (DRD1, DRD2 and …
8
… The results of our study obtained for the DRD2 gene demonstrate no statistically significant difference between rs1800497, rs1124493 and rs2242592 polymorphisms. They coincide …
9
… DRD2 Продемонстрирована ассоциация полиморфизма rs1124493 гена DRD2 с хорошим эффектом на терапию галоперидолом [21]. Результаты ряда исследований …
10
… Bu vo ap tik tas ry šys tarp rs1124493 po li mor fiz mo DRD2 ge ne, rs2242592 po li mor fiz … Ap tik ta, kad kli ni ki nė būk lė la biau pa ge rė jo tų pa cien tų, ku rie tu rė jo rs1124493 po li …
11
… In our study, we observed a significant effect of the rs2242592 and rs1124493 polymorphisms, within … Concerning the rs1124493 DRD2 polymorphism, it was previously reported to be …
12
Dopamine D2 receptors, encoded by DRD2, play a role in regulating serum prolactin concentration. Single nucleotide polymorphisms (SNPs), rs2734842(C), rs6275(T), and rs6279(C) …
13
With recent advances in understanding of the neuroscience of risk taking, attention is now turning to genetic factors that may contribute to individual heterogeneity in risk attitudes. In this …
14
Шизофрения представляет собой многофакторное расстройство, развивающееся под влиянием различных генетических, физиологических причин и факторов окружающей …
15
… stated that patients with the rs1124493 (SNP intron variant) had improved clinical outcomes as measured by a reduction in the PANSS score (p=0.001). LopezRodriguez et al.[49] …
16
Scientific understanding of precision medicine is rapidly evolving as new associations are made between genetic variants and tolerance to pharmaceuticals [1]. Although …
17
… Продемонстрирована ассоциациÿ полиморфизма rs1124493 гена DRD2 с хорошим эффектом терапии галоперидолом [21]. Результаты рÿда исследований подтверждают …
Curated Studies0

These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.

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Unused Studies0

No unused studies.