Genetics Research
rs11030119
Population Frequencies12
African
G 0.72016A 0.27984GG 0.520677GA/AG 0.398966AA 0.080357pop=51,072
African American
G 0.72046A 0.27954GG 0.520601GA/AG 0.399716AA 0.079683pop=49,270
African Others
G 0.712A 0.288GG 0.522752GA/AG 0.378468AA 0.098779pop=1,802
Asian
G 0.9578A 0.0422GG 0.916366GA/AG 0.082801AA 0.000834pop=7,198
East Asian
G 0.9645A 0.0355GG 0.929759GA/AG 0.069562AA 0.000679pop=5,894
European
G 0.719115A 0.280885GG 0.520504GA/AG 0.397223AA 0.082273pop=332,770
Latin American 1
G 0.7157A 0.2843GG 0.518732GA/AG 0.394027AA 0.087241pop=7,634
Latin American 2
G 0.78868A 0.21132GG 0.625309GA/AG 0.326735AA 0.047956pop=16,974
Other
G 0.75A 0.25GG 0.570157GA/AG 0.359685AA 0.070157pop=11,688
Other Asian
G 0.9271A 0.0729GG 0.855828GA/AG 0.142638AA 0.001534pop=1,304
South Asian
G 0.65A 0.35GG 0.444444GA/AG 0.411111AA 0.144444pop=540
Studies52
Unread Studies52 ▼
1
… understand the impact of rs11030119 on circulating levels of … GG or AA genotype of rs11030119 were matched for age and … In conclusion, rs11030119 modulates circulating and …
2
… De plus, les recherches ont exploré le polymorphisme rs11030119 du gène codant pour le BDNF, … Additionally, research on the rs11030119 polymorphism of the gene coding for BDNF …
3
The development of substance use disorders (SUDs) is partly determined by genetic factors. Brain-derived neurotrophic factor (BDNF) underlies the neurobiological mechanisms of …
4
This review examines the role of pharmacogenomics in individual responses to the pharmacotherapy of various drugs of abuse, including alcohol, cocaine, and …
5
… Only children homozygous for common alleles of rs429358, rs11030119, and rs962369 … ), whereas children being variant homozygotes of rs11030119 or rs962369 had lower scores (…
6
… This study suggests an association between BDNF polymorphisms (rs6265, rs11030119) and stroke risk in a South Indian population. Further research in larger populations is …
7
Gastric cancer (GC), the fifth most common cancer globally in 2020, shows high prevalence in Eastern Asia, Europe, and South America. Its complex pathogenesis is …
8
Addiction, albeit some disbelievers like Mark Lewis [1], is a chronic, relapsing brain disease, resulting in unwanted loss of control over both substance and non-substance behavioral …
9
O fator neurotrófico derivado do cérebro (BDNF) é expresso e presente na maioria das principais regiões cerebrais, especialmente no hipotálamo (centro do apetite), como um …
10
La población general está regularmente expuesta al plomo (Pb), el cual puede atravesar la barrera placentaria y provocar efectos adversos en el feto en desarrollo. Nuestro objetivo …
11
Drug addiction is a serious relapsing disease that has high costs to society and to the individual addicts. Treatment of these addictions is still in its nascency, with only a few examples of …
12
Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies …
13
… Also, besides BDNF Val66Met, it is reported that BDNF rs11030119 was independently associated with poor functional outcome after stroke. Therefore, further research using a genome…
14
Pre-synaptic secretion of brain-derived neurotrophic factor (BDNF) from noradrenergic neurons may protect the Alzheimer’s disease (AD) brain from amyloid pathology. While the BDNF …
15
Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making …
16
The efficacy of methadone maintenance treatment (MMT) in opioid use disorder is well established but responses vary. The influence of methadone pharmacodynamics and …
17
Genome-wide association studies (GWAS) have greatly expanded our understanding on the genetic architecture of cardiovascular disease in the past decade. It has revealed hundreds …
18
Genome-wide association studies (GWAS) have greatly expanded our understanding on the genetic architecture of cardiovascular disease in the past decade. It has revealed hundreds …
19
Brain-derived neurotrophic factor (BDNF) is associated with the risk for Alzheimer's disease and type 2 diabetes. The aim of this study was to examine the association of …
20
… Morris (8), the SNPs (rs11030119 and rs7124442) we validated successfully have a relatively low minor allele frequencies (MAFs). As it might be expected, the MAFs of our sample …
21
… A correlation was indicated between the rs11030119 SNP of the BDNF gene and favourable outcomes measured 7 years after the ischaemic stroke OR (0.6; 955CI: 0.42–0.86, p = 0.01) …
22
Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and …
23
This review will discuss recent studies that have employed pharmacogenetic findings to advance development of therapeutics and improve treatment outcomes for …
24
… For instance, the BDNF SNP rs11030119 was independently associated with poor mRS scores at 7 years after stroke, 4 and the BDNF rs6265 AA genotype was related to poor mRS at …
25
Genetic studies in obesity and eating disorders have identified brain-derived neurotrophic factor (BDNF) and neurotrophic receptor tyrosine kinase 2 (NTRK2) as candidate …
26
To identify susceptibility genes for osteoporosis, we conducted an integrative analysis that combined epigenomic elements and previous genome-wide association studies (GWASs) …
27
Genome-wide association study (GWAS) has been successful in identifying obesity risk genes by single-variant association analysis. For this study, we designed steps of …
28
… were found to have suggestive association with fracture (rs11030119: P=0.024; rs7124442: P… As such, fracture results of rs11030119 and rs7124442 would require replication in a larger …
29
Alcoholism has an estimated heritability of between 40 and 60 % and it is thought that several genes of small effect may contribute to the risk of developing this disorder. Studies of the …
30
The ubiquitous complexity of common diseases is one of the biggest challenges facing the field of personalized treatments and precision medicine. This complexity can be attributed to …
31
The brain-derived neurotrophic factor (BDNF) gene may influence eating behavior, body weight and cognitive impairments. We aimed to investigate whether BDNF genetic variability …
32
… However, rs11030119 was independently associated with poor functional outcome 7-years … more severe stroke, whereas rs11030107 and rs11030119 had a trend towards milder stroke…
33
Methadone, a synthetic opioid, is mainly used as an analgesic and a maintenance antiaddictive and reductive preparation in the treatment of opioid dependence. A better …
34
Obesity prevalence continues to increase worldwide, yet few safe and effective treatment options are available suggesting there needs to be a greater emphasis on preventing rather …
35
Bipolar disorder (BD) is a complex disorder with a number of susceptibility genes and environmental risk factors involved in its pathogenesis. In recent years, huge progress has been …
36
… The risk study showed that only the rs11030119 AA genotype increased the risk for AN (OR = 5.23 [1.32–20.98], p = 0.02), although the association lost significance after Bonferroni …
37
… The risk study showed that only the rs11030119 AA genotype increased the risk for AN (OR= 5.23 [1.32–20.98], p= 0.02), although the association lost significance after Bonferroni …
38
Individuals who are carriers of deletions of various sizes that cause haploinsufficiency in the contiguous WT1 and PAX6 genes, located on chromosome 11p13 approximately 4Mb …
39
40
Variability explained by the EU-PACT’s algorithm when applied to our (HULP) cohort was 44.4%. The real mean dose in patients with at least 1 of the evaluated variables (…
41
Suicidal behaviour is a phenotype widely associated with psychiatric disorders such as major depressive disorder and bipolar disorder. However, recent evidence indicates …
42
Cerebral palsy (CP) is a permanent disorder, affecting 2–3 per 1,000 live born children, disturbing movement and posture. Spastic limbs affects about 70–80% of the CP children, and …
43
… A haplotype consisting of six SNPs (rs7127507, rs1967554, rs11030118, rs988748, rs2030324, and rs11030119) of the brain-derived neurotrophic factor (BDNF) gene was found to be …
44
… SNPs rs11030107, rs10835210, rs7103873, rs11030119, and rs12273363 were genotyped using TaqMan ® SNP Genotyping Assays (Applied Biosystems, Melbourne, Australia). …
45
To date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that …
46
Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis…
47
Brain‐derived neurotrophic factor (BDNF) signaling pathways have been shown to be essential for opioid‐induced plasticity. We conducted an exploratory study to evaluate BDNF …
48
Murine models and association studies in eating disorder (ED) patients have shown a role for the brain‐derived neurotrophic factor (BDNF) in eating behavior. Some studies have …
49
Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have …
50
… We analyzed the rs6265, rs12273363 and rs11030119 polymorphism of the BDNF gene through a family-based association study. A total of 105 individuals grouped in family-…
51
… O alelo G do rs7124442 e o alelo A do rs11030119 foram associados a uma maior chance de exacerbação (OR= 1,575, Pperm= 0,037 e OR= 1,823, Pperm= 0,029). Além disso, o …
52
Antidepressant pharmacogenetics represent a stimulating but often discouraging field. The present study propose a combination of several methodologies across 3 independent …
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