Genetics Research
rs1047303
Threonine 367 → Asparagine
Gene: HSD3B1 — Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1
Chr 1:119514623
1p12
Missense Variant
Population Frequencies12
African
C 0.12263A 0.87737CC 0.02121CA/AC 0.202847AA 0.775943pop=14,050
African American
C 0.12429A 0.87571CC 0.021842CA/AC 0.204903AA 0.773254pop=13,460
African Others
C 0.085A 0.915CC 0.00678CA/AC 0.155932AA 0.837288pop=590
Asian
C 0.082A 0.918CC 0.032609CA/AC 0.097826AA 0.869565pop=184
East Asian
C 0.075A 0.925CC 0.033333CA/AC 0.083333AA 0.883333pop=120
European
C 0.32068A 0.67932CC 0.104852CA/AC 0.431666AA 0.463482pop=50,414
Latin American 1
C 0.252A 0.748CC 0.047297CA/AC 0.408784AA 0.543919pop=592
Latin American 2
C 0.184A 0.816CC 0.048611CA/AC 0.270833AA 0.680556pop=864
Other
C 0.2867A 0.7133CC 0.087697CA/AC 0.397963AA 0.514339pop=9,624
Other Asian
C 0.09A 0.91CC 0.03125CA/AC 0.125AA 0.84375pop=64
South Asian
C 0.186A 0.814CC 0.019608CA/AC 0.333333AA 0.647059pop=102
Studies12
Unread Studies12 ▼
1
Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies.
2
Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer.
3
Genetic variations predicting progression with docetaxel and novel androgen-receptor pathway inhibitors.
4
Impact of trough abiraterone level on adverse events in patients with prostate cancer treated with abiraterone acetate.
5
Association Between Adrenal-Restrictive HSD3B1 Inheritance and Hormone-Independent Subtypes of Endometrial and Breast Cancer.
6
Clinical impact of HSD3B1 polymorphism by metastatic volume and somatic HSD3B1 alterations in advanced prostate cancer.
7
Prostate Cancer Mortality Associated with Aggregate Polymorphisms in Androgen-Regulating Genes: The Atherosclerosis Risk in the Communities (ARIC) Study.
8
HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond.
9
Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone.
10
Interactions between dietary acrylamide intake and genes for ovarian cancer risk.
11
Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.
12
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
Curated Studies0 ▼
These studies were determined to be useful for this variant — check "Unused Studies" further down if curious what didn't make the cut.
No curated studies yet.
Unused Studies0 ▼
No unused studies.